Modeling Ca2+ diffusion in brain extracellular space
نویسندگان
چکیده
Molecular diffusion in brain extracellular space (ECS) is primarily controlled by interactions with the geometry and the interstitial matrix. Both factors increase λ, the tortuosity, a measure of hindrance to diffusion where λ2 = D/D∗ with D the free diffusion coefficient and D∗ the effective diffusion coefficient in brain [1]. Geometry lengthens diffusion paths or creates holdup in local voids of deadspaces in the ECS [2] and matrix interacts via specific binding reactions, some illustrated in Fig. 1a.
منابع مشابه
Modeling Brain Extracellular Space from Diffusion Data
The extracellular space (ECS) of the brain is a thin region surrounding each cell that is filled with a medium resembling cerebrospinal fluid and an unknown amount of extracellular matrix. The ECS is difficult to study but diffusion measurements based on a point-source diffusion paradigm have begun to reveal the complex structure of this region. Despite the complexity, a modified version of Fic...
متن کاملComputational modeling of cerebral diffusion-application to stroke imaging.
Water diffusion within the structure of a brain extracellular space is analyzed numerically for various diffusion parameters of brain tissue namely extracellular space porosity and tortuosity. An algorithm for predicting diffusion pattern of water molecules within human brain considering the mechanics of water diffusion within porous media is developed. The extracellular space is modeled as a h...
متن کاملWound-induced Ca2+ wave propagates through a simple release and diffusion mechanism
Damage-associated molecular patterns (DAMPs) are critical mediators of information concerning tissue damage from damaged cells to neighboring healthy cells. ATP acts as an effective DAMP when released into extracellular space from damaged cells. Extracellular ATP receptors monitor tissue damage and activate a Ca2+ wave in the surrounding healthy cells. How the Ca2+ wave propagates through cells...
متن کاملControl and plasticity of intercellular calcium waves in astrocytes: a modeling approach.
Intercellular Ca2+ waves in astrocytes are thought to serve as a pathway of long-range signaling. The waves can propagate by the diffusion of molecules through gap junctions and across the extracellular space. In rat striatal astrocytes, the gap-junctional route was shown to be dominant. To analyze the interplay of the processes involved in wave propagation, a mathematical model of this system ...
متن کامل